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Carcinogenesis Within a life time carcinogenicity study completed in B6C3F1 mice, methylphenidate brought on a rise in hepatocellular adenomas, and in males only, an increase in hepatoblastomas at a everyday dose of roughly sixty mg/kg/working day. This dose is around two times the MRHD of 60 mg/working day given to young children on mg/m2 foundati